Neurological diseases called Parkinson disease are associated with gamma-aminobutyric acid (GABA) cause to depletion in brain. Antioxidant activity present in White mulberry leaves is GABA-enriched, which may provide a neuroprotective effect against cerebral ischemia as well as neurotoxins. White mulberry leaf extracts contain antidopaminergic activity mediated through dopamine D2 receptors as documented by (a) Reducing haloperidol and metoclopramide-induced catalepsy in mice (b) Blocking amphetamine-induced stereotyped behavior (such as schizophrenia) (c) And increasing the sensitivity to barbiturates.

White mulberry regulates lipid metabolism, body weight gain, and adipose tissue by changing the expression of hepatic target genes in high-fat, diet-induced, obese mice. Melanin-concentrating hormone (MCH) is involved in feeding and energy metabolism. White mulberry leaf extract exhibits an antagonistic effect to MCH1 receptor in diet-induced obese mice, resulting in decreased body weight and adiposity, food intake, and hepatic lipid accumulation.

Morin extracted from white mulberry, at 80 mg/kg, exhibits hypouricemic action and inhibits xanthine oxidase in oxonate-induced hyperuricemic rats. The activity on urate uptake in rat renal brush border membrane vesicles was more potent than that of the prescription agent probenecid. Morin exhibits similar activity on urate transport in the human kidney.

The leaves and roots of Mulberry can suppress the growth of infections caused by parasites. The use of gooseberry can be traced to traditional folk medicines.

There are four types of kidney stones. The most common type of stone is the calcium oxalate stone. These stones can be prevented by daily consumption of mulberry juice. Uric acid stones are often found in people with gout, but they may also occur in those who are dehydrated or who eat a high-protein diet. Struvite stones are connected with urinary tract infections. They can grow quickly and become large. Cysteine stones are the least common, and result from a hereditary disorder that causes the kidneys to excrete excessive amounts of some amino acids. Mulberries are added to medicines to strengthen the kidneys.

In Chinese medicine, a mulberry is considered as blood tonic, as they cleanse the blood and increase its production and strengthens the entire system.

In Chinese medicine, mulberry leaf tea is known as a cooling remedy that treats the liver and lung meridians. It removes lung heat symptoms such as fever, sore throat and cough, and it clears fire in the liver, that mean it removes symptoms such as dry, painful and watery eyes.

Extracts from Mulberry roots have sedative effects .It has found that it has analgesic and sedative component damnacanthal. It is recommended to treat menstrual cramps and other pains. Mulberry fruit juices were found to increase joint health and mobility. The juice can also help to prevent bone problems like arthritis and other skeletal disorders. Mulberry has xeronine and KB-C ingredients which aid in minimizing pain and swelling, relieving inflammatory conditions, and fortifying weak bones and ligaments.

A substance from mulberry root bark extract identified as albanol triggers cell death in human leukemia cells. It also suggests that mulberry extracts should not be used by anyone undergoing chemotherapy without the approval and supervision of a physician..

Mulberry extract is incorporated into skin-whitening products. The compound attributed with lightening the skin is arbutin, a form of hydroquinone that inhibits melanin release by suppressing the tyrosinase enzyme. A team of French researchers analyzed two cases of squamous cell carcinoma in women who had been using skin-lightening products for more than a decade. While they could not say for certain that hydroquinone agents were the direct cause of either cancer, they did note that the carcinogenic side effects of hydroquinone are well established in animal models.

White mulberry might lower the blood sugar levels in people for those who suffer from diabetes. Watch out the signs of low blood sugar (hypoglycemia) carefully if you have diabetes and use white mulberry.

Avoid use during pregnancy and lactation due to lack of clinical data.